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Vinpocetine(CAS 42971-09-5) for promoting blood circulation

Date : 2016/10/14 11:25:33

The study of Chinese herbal preparation such as vinpocetine(CAS 42971-09-5) for promoting blood circulation and removing blood stasis, although the results were positive, the number of cases and the observation time were not long enough to result in the low level of evidence.

Piracetam, citicoline and antidepressants (fluoxetine, triazolone, etc.) in the treatment of vascular dementia in relatively few studies, and its efficacy has been questioned.

In the treatment of cognitive dysfunction, cholinesterase inhibitors (donepezil, rivastigmine, galantamine, etc.) and N-methyl-D-aspartate (NMDA) receptor antagonists are the most common Agent (memantine). In addition, calcium antagonists (nimodipine), blood circulation of traditional Chinese medicine preparations such as vinpocetine(CAS 42971-09-5), brain cell activator (piracetam, citicoline), antidepressants (fluoxetine, Etc.), and for the treatment of underlying diseases (antihypertensive drugs, hypoglycemic agents, antiplatelet drugs, statins) and so on.

More than 10 years of diabetes, 65 years of age before the risk of diabetes, insulin or oral hypoglycemic agents and patients with diabetic complications of vascular dementia increased risk of stroke patients, 16-24% of patients with diabetes or later diagnosed with diabetes diabetes. Therefore, control of blood glucose, diabetes itself and the prevention of vascular dementia are effective. Hypertension and vascular dementia have also been similar results. Therefore, the treatment of underlying diseases (antihypertensive drugs, hypoglycemic agents, antiplatelet drugs, statins) is actually through the secondary prevention of cerebrovascular disease and delayed decline in cognitive function. In the case of statins, inhibition of delayed brain injury following inflammatory injury may be a possible mechanism for the benefit of VaD patients.

In short, the pathophysiology of vascular dementia is unknown, possible mechanisms include: cholinergic insufficiency, vascular or circulatory dysfunction, ischemic injury caused by delayed inflammatory response to delayed brain injury. Among them, the hemodynamic dysfunction is one of the key areas of neurology research, prevention of vascular disease is one of the most viable strategies to prevent vascular dementia. Especially in the acute phase of treatment, for the presence of VCI but not yet achieved dementia in patients with partial control, or even reversal of cognitive impairment symptoms.