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3,4-Dihydroxybenzaldehyde(cas 139-85-5) and the treatment of platelet aggregation

Date : 2016/8/31 11:19:31

3,4-Dihydroxybenzaldehyde(cas 139-85-5) has a function of anti-platelet aggregation.

The significance of platelet aggregation rate:

Platelet aggregation rate is a test of platelet function index. Increased platelet aggregation rate, platelet easily gathered thrombus formation, the higher its value, are more likely to have thrombosis. At the same time of thrombosis, TXA2 thromboxane (2) write, also cause coronary artery spasm, make all microcirculation disorder.  

In arteriosclerosis, coronary heart disease, cerebral infarction, thrombotic diseases such as hypertension, diabetes, platelet aggregation rate tends to rise. Through treatment, the platelet aggregation rate when left, it not only can inhibit thrombosis, still can make has formed the thrombolysis, so the determination of platelet aggregation rate can have the effect of the treatment, screening drugs. For there is no such disease increased platelet aggregation rate of former state (thrombosis), which can be as an important reference index to predict the disease, if prompt adoption of reasonable treatment measures according to the index, is likely to prevent this kind of disease. We can use 3,4-dihydroxybenzaldehyde(cas 139-85-5) for prevent platelet aggregation.

Treatment countermeasures:

(1) Use 3,4-dihydroxybenzaldehyde(cas 139-85-5).
(2) aspirin and clopidogrel is the common effective drugs.  
Aspirin inhibited oxidase, can reduce arachidonic acid synthesis of prostate peroxide (PGG2 and PGH2) and thrombosis A2 (TXA2), reduce the rate of platelet aggregation. Clopidogrel is an ADP receptor antagonist, platelet optional its active metabolites, irreversible combined with ADP receptor P2Y12 platelet membrane surface, thereby inhibiting platelet aggregation. Aspirin doses: 75-325 mg, 75-150 mg dose; Clopidogrel doses: 300-600 mg loading dose, maintenance dose of 75 mg. Due to the above two drugs mechanism of complementary both share to enhance curative effect. Experiments that night antiplatelet drugs clinical curative effect of aspirin and clopidogrel is better than that of daytime use. Of aspirin and clopidogrel resistance at present, about 4-30% of the two drugs have some side effects, should follow the doctor's advice.  

(3) research has shown that patients with blood stasis syndrome of TCM increased platelet aggregation rate, drug treatment for activating blood circulation can reduce platelet aggregation rate. In vitro experiments show that ginseng saponin (ginseng ingredients) strongest inhibition of platelet aggregation rate. 

Literature reports: compound danshen dropping pill, ripe tomatoes, cabbage juice, have the effect that reduce platelet aggregation rate. Also have reported, aerobic exercise can reduce the expression of platelet glycoprotein surface receptors, prompted the platelet aggregation rate is reduced, its mechanism is unknown, may be related to promote the synthesis of the human body NO release, increase the plasma concentration of NO.