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The brain central role of tianeptine sodium(CAS 30123-17-2)

Date : 2016/8/30 10:57:58

The brain central role of tianeptine sodium(CAS 30123-17-2): IBS patients with multiple concurrent psychiatric disorders, such as depression, anxiety, fear, anxiety and tension dominant role in the course of IBS. People's emotions is mainly affected by the limbic system control, the limbic system also can regulate the endocrine and autonomic functions. Brain - gut axis by the autonomic nervous system (ANS) and the combined effect of the HPA axis, CRF is brain - gut axis response to stress an important medium, antidepressants acting on the limbic system, reduce CRF, reduce stress on the HPA axis activation, while improving mental state can relieve IBS symptoms.

Visceral hypersensitivity and central nervous system (CNS) anomalies on pain perception plays an important role in the pathogenesis of IBS. Anterior cerebral cingulate cortex (ACC) and the insular cortex (IC) is the hub of visceral pain, the abnormal excitability on central processing visceral pain, leading to allodynia, produce abdominal pain. The study found, IBS patients with CNS colorectal distension pain perception threshold lower than normal, suggesting that TCAs may act on ACC and IC, by raising the central pain threshold relieve intestinal symptoms. Dekel et al note that antidepressant drugs can inhibit the synaptic cleft NA, 5-HT reuptake analgesic effect. A Japanese study showed that damage to neurons involved in the pathogenesis of mental disorders. Uzbay noted tianeptine sodium(CAS 30123-17-2) can promote hippocampal neuronal regeneration, reduce apoptosis, strengthen neuronal plasticity, and thus anti-anxiety and depression, treatment of IBS. Grover et noted that antidepressant drugs reduce central pain, relieve psychological complications, both antiemetic and improve well-being, improve sleep and so on.

Abdominal symptoms: abdominal pain and abdominal discomfort are the most common symptoms in patients with IBS. Antidepressant drugs can significantly improve symptoms of abdominal pain or IBS. Greck other studies have found that mental and psychological disorders IBS patients receiving antidepressant drug treatment of abdominal pain was significantly alleviated. Poitras and other studies have shown that small doses of amitriptyline can reduce IBS patients with dilated rectal sensitivity, relieve abdominal pain, bloating. Tack such as the use of citalopram in patients with IBS cross-controlled trial, the results showed that compared with placebo, citalopram significantly improved abdominal pain and other IBS symptoms, and not affected by the emotional and psychological symptoms of intestinal sensory motor function. Ford et a systematic review and meta-analysis showed that antidepressant drugs for the treatment of IBS has a good effect, especially in terms of ease abdominal pain or discomfort.