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Tianeptine sodium(CAS 30123-17-2) and antidepressants

Date : 2016/8/26 11:21:52

Discussion on functional dyspepsia (FD) mechanism gastrointestinal adverse reactions in patients beginning antidepressant therapy, evaluation of antidepressants in the treatment of FD security. Methods: 57 cases of FD were randomly divided into two groups, the study group of 30 patients and a control group of 27 patients. The former administering treatment with SSRIs, tianeptine sodium(CAS 30123-17-2) treatment given to the latter, the two groups after treatment statistical adverse gastrointestinal reactions types and incidence, and learn about adverse reactions and duration of the relationship between the two drugs gastrointestinal tract. Results: Study Group of gastrointestinal adverse events was significantly higher, and occurred in the treatment of early stage, with the duration of treatment, adverse symptoms gradually reduced. Conclusion: Selective serotonin reuptake inhibitors (SSRIs) is a new antidepressant, gastrointestinal adverse serotonin concentration in the reaction occurs with a sudden increase in gastrointestinal environment related to the role of the latter in the gastrointestinal tract serotonin receptor subtypes, causing various gastrointestinal adverse reactions.

In clinical practice, in order to increase efficacy and reduce side effects, doctors often will antidepressants in combination with different mechanisms of medicine(tianeptine sodium(CAS 30123-17-2) with other drugs for example). In this regard, the patient should be prescribed medication. However, for the sake of quick, several antidepressants without the same mechanism of action (eg thirty-four kinds serotonin reuptake inhibitor) combined with long-term use is wrong. Because of this blind medication may cause adverse reactions, and even lead to antidepressant treatment of the most serious adverse reactions --5- serotonin syndrome, mental status changes (confusion, hypomania); and myoclonus , hyperreflexia, sweating, chills, tremors, diarrhea, ataxia, fever, life-threatening.