sales@jinjingroup.com

  News Introduction

Tianeptine sodium(CAS 30123-17-2) belongs to tricyclic antidepressant

Date : 2016/8/24 11:28:00

Research of antidepressants fluoxetine and tianeptine sodium(CAS 30123-17-2) model of chronic stress depression rats hippocampal nerve growth factor (NGF plays) expression. Methods: rats were randomly divided into depression model group and the fluoxetine group, tianeptine sodium group and the control group. Model group, the fluoxetine group and tianeptine sodium group was given 21 d stress, this time in the control group normal breeding, stimulate the fluoxetine group during daily lavage fluoxetine (10 mg/kg), tianeptine sodium group every day lavage tianeptine sodium(50 mg/kg), model group and control group every day by gastric volume of normal saline. Behavioral science experimental detection method of the opening and liquid consumption. Using Western Blot method to detect each model NGF expression of hippocampus in rats. Results after the stress level of model group through the bars, erect, modify number, sugar water consumption percentage were significantly lower than the control group (P0.01). Fluoxetine group after stress levels across several, erect, modify times and sugar water consumption percentage are higher than model group (P0.05). 

Stress after tianeptine sodium(CAS 30123-17-2) sugar water consumption percentage is higher than the model group (P0.05), level through the bars, erect times and modification times higher than that of model group, but there was no statistically significant difference. In the Western blotting method tests, after chronic stress model group rats hippocampal model NGF expression level was significantly lower than the control group (P0.01); Fluoxetine group rats hippocampal model NGF expression level is higher than model group (P0.01), and there was no statistically significant difference in the control group (P0.05); tianeptine sodium(CAS 30123-17-2) group rats hippocampal model NGF expression level is higher than the model group (P0.01), but slightly lower than the control group and the fluoxetine group there was no statistically significant difference (P0.05). Conclusion: chronic stress can lead to a drop in the rat hippocampus model NGF expression, fluoxetine and thiamethoxam nai leptin can reverse the chronic stress depression model rats model NGF expression in the hippocampus.

What are the drug treatment of depression?

1) tricyclic antidepressants: such as doxepin, imipramine, clomipramine, amitriptyline. Such drugs have anticholinergic side effects, can cause dry mouth, blurred vision, difficulty urinating, constipation, cardiotoxic when over-taking, cross each other allergic reactions, the elderly increased sensitivity of the medicines The amount to be reduced.
2) selective serotonin reuptake inhibitors: such as fluoxetine, paroxetine, sertraline, citalopram, and the like. The therapeutic effect of these drugs and the onset time and was first used to treat depression tricyclic same, but the small adverse reactions, without the need for dietary restrictions. 3) norepinephrine reuptake inhibitors: such as maprotiline.
4) a selective serotonin and norepinephrine reuptake inhibitors: such as venlafaxine. 
5) monoamine oxidase inhibitors: such as moclobemide. 
6) Other antidepressants: such as(CAS 30123-17-2), trazodone and so on.