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The development of tianeptine sodium(CAS 30123-17-2)

Date : 2016/8/18 11:10:15

Tianeptine sodium(CAS 30123-17-2) tradename is tatinol, 2001 in the domestic market. Antidepressant mechanism and not the traditional TCA.The same can be increased uptake in the synaptic cleft 52HT and 52HT and NA reuptake of action is weak. They may enhance neuronal transmission 52HT. Hands effect. The M receptor, H1 receptor, α1 and α22NA no affinity receptors. Antidepressant efficacy of the products and TCA similar security.

And better tolerated than TCA. This product is similar to the efficacy of SSRI fluoxetine. The main side effects were gastrointestinal symptoms, such as dry mouth, nausea, abdominal pain and diarrhea, as well as other insomnia, dizziness, headache. This product is very short elimination half-life of about 2.5h. Dose of 12.5mg, tid.

Development of psychotropic substances such as tianeptine sodium(CAS 30123-17-2), has been much progress in recent years, the development of a series called the second generation of antipsychotics and antidepressants. Compared with the first generation of drugs, pharmacological mechanism of the second-generation drugs are different, broader therapeutic effect, safety and better tolerated. Second generation antipsychotics is characterized by a broader spectrum of action on negative symptoms, cognitive deficits has a good effect; there are better tolerated, improved patient compliance with treatment. Characteristics of second-generation antidepressants because of fewer adverse reactions to extend the applicability of the crowd.

Nearly 10 years, especially in the past three to five years, the spirit of drug research in the field is very active in the world, a large number of new psychotropic drugs including tianeptine sodium(CAS 30123-17-2) entering each phase of clinical trials, new drugs have been approved in some countries listed. China in recent years have also been a lot of phases of clinical trials of new drugs imported and domestic imitation, some of the new antidepressants, anti-anxiety drugs and drug treatment of insomnia due to having a safe, simple and easy to use the advantages of being widely clinical application.