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Tianeptine sodium(CAS 30123-17-2) improves patient sleep

Date : 2016/8/23 11:59:47

Comparison the effect of sleep disorders after cerebral hemorrhage rate of EEG abnormalities improve with tianeptine sodium(CAS 30123-17-2) and simple application of the sedative. Methods: 62 patients were randomly divided into tianeptine group and conventional treatment group 31 cases. Thiophene tianeptine group was given oral tianeptine tablets, 12.5mg / time, 3 times / d. conventional treatment group tricyclics, phthalic nitrogen Zhuo drugs and chloral hydrate and other treatment, are 1 / d bedtime when recorded before treatment and 2 weeks of treatment in patients with sleep EEG and improve the situation. The results showed that tianeptine group of sleep disorders integral (2.65 ± 0.19) before treatment (5.97 ± 0.44) comparison (t = 66.3 , P <0.05), the total EEG abnormal rate of 12.4%. conventional treatment of sleep disorders integral group (2.58 ± 0.52) before treatment (6.54 ± 0.54) comparison (t = 37.40, P <0.01), the total EEG abnormalities rate of 45.2%, after treatment of sleep disorders Integra (t = 1.0, P> 0.05), the total EEG abnormality rate between (x 2 = 4.72, P <0.05). Conclusion: plus tianeptine improves patient sleep and sedation in patients compared with conventional EEG improvement on the obvious.

Discuss the efficacy and safety of tianeptine sodium(CAS 30123-17-2) treatment senile depression. Methods: 62 patients with senile depression were randomly divided into two groups, were given tianeptine and amitriptyline in treatment for 6 weeks. Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) to evaluate the efficacy, adverse reactions Assessment of adverse reactions Scale (TESS). Results: tianeptine and amitriptyline similar efficacy, no serious adverse reactions. Conclusion: tianeptine sodium(CAS 30123-17-2) treatment of senile depression efficacy, fewer side reactions, the patient medication compliance is good.

Detection episode depression before and after treatment in patients with hippocampus volume and neurological changes in compounds, combined with plasma cortisol concentration, treatment effects, depression scores, age, sex, duration and other factors discussed episode depression Is there evidence of neural plasticity in the hippocampus, and such changes may investigate neural plasticity factors. Subjects and Methods: from April 2005 to April 2007 to Capital Medical University, 23 cases of outpatients diagnosed with depression starting Beijing Anding Hospital, 12 males and 11 females, aged 19-50 years, mean 31.57 ± 9.60 years, were first met the diagnostic criteria for depression and exclusion criteria before enrollment were not medication.