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Test of tianeptine sodium(CAS 30123-17-2) tablets dissolution

Date : 2016/8/15 14:03:22

Establish tianeptine sodium(CAS 30123-17-2) tablets dissolution test method. Method: water as dissolution medium basket method, speed 10 0r / min, 4 5min of sampling points, detection wavelength 2 2 5nm. Results: thiophene sodium in 2 .74 ~ 2 7.4 4 μg · ml-1 range, concentration and absorbance was linear relationship (r = 0 .9998). Recoveries 10 0 .1%, RSD 0.6 to 1%, the average of three batches of dissolution greater than 90%. Conclusion: The method is simple, rapid and tianeptine sodium tablets for the in vitro dissolution monitoring provides a method.
Comparison plus tianeptine and simple application of sedative drugs for sleep disorders after stroke rate of EEG abnormalities improved results. Methods: 62 patients were randomly divided into tianeptine group and conventional treatment group 31 cases. tianeptine group was given oral tablets tianeptine, 12.5 mg / time, 3 times / d. conventional treatment group tricyclics, benzodiazepines (troponyl) drugs and chloral hydrate and other treatment, were 1 times / d, bedtime when recorded before treatment and 2 weeks of treatment in patients with sleep and EEG inspection results tianeptine group of sleep disorders integral (2.65 ± 0.19) before treatment (5.97 ± 0.44) have more significant difference (t = 66.3, P <0.05), EEG total abnormal rate of 12.4%. conventional treatment group of sleep disorders integral (2.58 ± 0.52) before treatment (6.54 ± 0.54) were significantly different (t = 37.40, P <0.01), the total EEG abnormality rate 45.2%, sleep disorders integral difference between the two groups after treatment was not significant (t = 1.0, P> 0.05), there was significant difference in total EEG abnormality rate (x2 = 4.72, P <0.05). Conclusion: plus tianeptine sodium(CAS 30123-17-2) can improve sleep in patients, and compared with conventional sedation for patients EEG improvement is obvious.
Development of antidepressants has made great progress in recent years, such as tianeptine sodium(CAS 30123-17-2), the pharmacological mechanism for the first generation of antidepressants inhibit the 5-HT (5-HT) and noradrenaline (NA) reuptake receptors, the second generation of anti depression drugs are selective 5-HT reuptake inhibitor (SSRI) for the pilot .SSRI the basis of their pharmacological properties specially designed single pharmacological effects of the drug, its efficacy with conventional tricyclic antidepressants (TCA) almost no difference, but safety and tolerability has been greatly improved. SSRI indications in addition to depression, but also to treat obsessive-compulsive disorder and bulimia nervosa. Currently, five kinds of SSRI products have been listed in China. At the same time, recent years also developed a selective NA reuptake inhibitors (NAI), 5-HT and NA reuptake inhibitors (SNRI), NA with specific 5-HT can antidepressants (NaS-SA) and a series of new antidepressant drugs. This paper reviewed the literature for new antidepressant drugs in the domestic market in recent years to make a brief.