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Academic Research: Basic and clinical research of tianeptine sodium(CAS 30123-17-2)

Date : 2016/8/23 11:57:30

Binding and cell function analysis, including for G protein activation and accumulation of cAMP BRET analysis, researchers found that tianeptine sodium(CAS 30123-17-2) is an effective human μ- opioid receptor (MOR) agonists by using the radioligand. Meanwhile, although the performance is much lower than the μ- opioid receptor, the drug is completely human δ- opioid receptor (DOR) agonists. In contrast, the tianeptine sodium(CAS 30123-17-2) of κ- opioid receptor (KOR) no activity in humans and rats is true.

Based on the above pharmacological data, the researchers believe that the MOR separate activation or activation of the double effect MOR and DOR medicine may lead to a variety of acute or chronic effects of the initial molecular events, including anxiety and antidepressant effects.

Since 1973, researchers have been found in the brain and spinal cord of the opioid receptors, these receptors are distributed in the pain transduction region associated with emotional and behavioral areas. Opioid receptors are known μ, δ, κ, and other subtypes of acute effects of these receptors, including inhibition of adenylate cyclase activating K + conduction suppressing Ca conduction and neurotransmitter release.