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Tianeptine sodium(CAS 30123-17-2) can promote hippocampal neuronal regeneration

Date : 2016/8/10 10:55:13

Visceral hypersensitivity and central nervous system (CNS) anomalies on pain perception plays an important role in the pathogenesis of IBS. Anterior cerebral cingulate cortex (ACC) and the insular cortex (IC) is the hub of visceral pain, the abnormal excitability on central processing visceral pain, leading to allodynia, produce abdominal pain. The study found, IBS patients with CNS colorectal distension pain perception threshold lower than normal, suggesting that TCAs may act on ACC and IC, by raising the central pain threshold relieve intestinal symptoms. Dekel et al note that antidepressant drugs can inhibit the synaptic cleft NA, 5-HT reuptake analgesic effect. A Japanese study showed that damage to neurons involved in the pathogenesis of mental disorders. Uzbay noted tianeptine sodium(CAS 30123-17-2)  can promote hippocampal neuronal regeneration, reduce apoptosis, strengthen neuronal plasticity, and thus anti-anxiety and depression, treatment of IBS. Grover et noted that antidepressant drugs reduce central pain, relieve psychological complications, both antiemetic and improve well-being, improve sleep and so on.
Currently, medications for depression and related disorders, there are still many problems, including the response rate is low, slow onset, efficacy and decreased over time and serious side effects. Therefore, we need to explore new treatment options. A study published in the "conversion of Psychiatry" (Translational Psychiatry (2014) 4, e411;) study showed that atypical antidepressant tianeptine sodium(CAS 30123-17-2)  can activate μ- opioid receptor, this unique mechanism of action or make its circumvent these limitations.
In fact, basic and clinical research tianeptine sodium(CAS 30123-17-2)  has been carried out for more than 30 years, but its molecular targets and mechanism of action remains unclear. The study conducted by Columbia University M M Gassaway, aimed to discuss the above issues.