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The efficacy and safety analysis of tianeptine sodium(CAS 30123-17-2) and fluoxetine in treatment of depression

Date : 2016/8/4 11:53:18

Objective: To investigate the tianeptine sodium(CAS 30123-17-2) and fluoxetine in the treatment of depression efficacy and safety analysis. Methods: 120 depression patients were randomly divided into two groups, fluoxetine and tianeptine group, the experimental group of 60 patients, the use of thiophene tianeptine treatment, 60 patients fluoxetine group, the use of fluoxetine treatment, 8 weeks after treatment, Hamilton depression scale therapeutic effect was evaluated using the scale of adverse reactions to adverse drug reactions were evaluation results tianeptine group and fluoxetine treatment groups were effective, compared the two groups was not statistically significant (P <0.05). two groups of patients after 2 weeks of onset, tianeptine sodium(CAS 30123-17-2) fluoxetine group was significantly higher than in 2,4 and Hamilton depression fraction minus 8 weeks (P <0.05). the main toxicities tianeptine group performance for dry mouth, difficulty sleeping, gastrointestinal reactions , headache, constipation, compared with fluoxetine group, significantly less toxicity Conclusion: tianeptine treatment for depression a significant effect, lower toxicity, better than fluoxetine.
Tianeptine sodium(CAS 30123-17-2) fluoxetine treatment of depression in patients with a systematic review: Objective: To evaluate the tianeptine and fluoxetine in the treatment of depression efficacy and safety. Methods: We searched Chinese Journal Full-text database VIP, Wanfang database, Pub Med, Medline, EMBase regarding tianeptine and fluoxetine in treatment of depression randomized controlled trial (RCT), RCT included on the Cochrane systematic the method of evaluation was evaluated using Rev Man 5.0 statistical software for Meta analysis. Results A total of five studies, a total of 942 cases of patients, meta analysis showed that patients tianeptine efficiency [OR = 1.25,95% CI (0.93,1.66), P = 0.13] and the difference between the fluoxetine group no statistically significant; incidence of adverse reactions in the two groups was statistically significant difference [OR = 0.53,95% CI (0.36 ~ 0.77), P0.001]. Conclusion tianeptine sodium(CAS 30123-17-2) and fluoxetine in the treatment of depression as effective as, and less adverse reactions. However, this conclusion still need high-quality, carefully designed need RCT confirmed.