sales@jinjingroup.com

Products


30123-17-2 News

  Products > Chemical Intermediate > 30123-17-2

Product Name:
Tianeptine sodium
CAS No:
30123-17-2
Usage:
ADF
Online Order:
Online air
 
Message Online

Product Introduction

Basic information of Tianeptine sodium(CAS 30123-17-2):
Product Name: Tianeptine sodium
Chemical Name: Heptanoic acid,7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]-,sodium salt (1:1)
CAS No.: 30123-17-2
Formula: C21H24ClN2NaO4S
Molecular Weight: 458.93
Synonyms: Heptanoic acid, 7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]-,monosodium salt (9CI);Dibenzo[c,f][1,2]thiazepine, heptanoic acidderiv.;Sodium7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoateS,S-dioxide;Stablon;Tianeptine sodium;
EINECS: 250-059-3
Density: 1.38 g/cm3
Melting Point: 180 °C
Boiling Point: 609.2 °C at 760 mmHg
Flash Point: 322.2 °C
Appearance: white to yellowish powder
Storage: Store in dry, dark and ventilated place

The Tianeptine sodium(CAS 30123-17-2), with the CAS registry number 30123-17-2 and EINECS registry number 250-059-3, has the systematic name of sodium 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoate. It is a kind of white to yellowish powder, and belongs to the following product categories: Intermediates & Fine Chemicals; Pharmaceuticals. And the molecular formula of the chemical is C21H24ClN2NaO4S.

The characteristics of Tianeptine sodium(CAS 30123-17-2): (1)ACD/LogP: 2.57;(3)ACD/LogD (pH 5.5): 0.22; (2)ACD/LogD (pH 7.4): 0.02; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 2.67; (6)ACD/KOC (pH 7.4): 1.7;(7)Polar Surface Area: 86.3 ?2; (8)Flash Point: 322.2 °C; (9)Enthalpy of  Vaporization: 95.15 kJ/mol; (10)Boiling Point: 609.2 °C at 760 mmHg; (11)Vapour Pressure: 1.08E-15 mmHg at 25°C.
Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: [Na+].[O-]C(=O)CCCCCCNC3c1c(cc(Cl)cc1)S(=O)(=O)N(c2c3cccc2)C
(2)InChI: InChI=1/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1/p-1
(3)InChIKey: ZLBSUOGMZDXYKE-REWHXWOFAT

“Global and Chinese Tianeptine sodium(CAS 30123-17-2) Industry - 2016”:
The 'Global and Chinese Tianeptine sodium(CAS 30123-17-2) Industry 2016' is a professional and in-depth study on the current state of the global Tianeptine sodium(CAS 30123-17-2) industry with a focus on the Chinese market. The report provides key statistics on the market status of the Tianeptine sodium(CAS 30123-17-2) manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.
Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company.
Through the statistical analysis, the report depicts the global and Chinese total market of Tianeptine sodium(CAS 30123-17-2) industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates 2016-2021 market development trends of Tianeptine sodium(CAS 30123-17-2) industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out.
In the end, the report makes some important proposals for a new project of Tianeptine sodium(CAS 30123-17-2) Industry before evaluating its feasibility. Overall, the report provides an in-depth insight of 2011-2021 global and Chinese Tianeptine sodium(CAS 30123-17-2) industry covering all important parameters.

Question1:Tianeptine sodium(CAS 30123-17-2) Salt vs Free Acid (self.Nootropics)
How do the two differ? Is one more potent than the other? Are the dosing the same? Please teach me.Free Acid is cheaper than the Sodium Salt so I figure there must be a reason.
Answers:
1.Tianeptine sodium(CAS 30123-17-2) is the sodium salt form of Tianeptine. It is the most common form of Tianeptine. It is water soluble. It is highly orally bioavailable, and is absorbed rapidly if ingested, leading to an immediate sharp rise in Tianeptine concentrations in the body / no sustained absorption so rapid tailoff. The sodium salt form is (usually) very hygroscopic, and if in the form of a raw powder, the sodium salt turns to goo when exposed to atmospheric humidity.
Tianeptine free acid is Tianeptine itself, not a salt of Tianeptine. This form is not water soluble. Unpublished research suggests Tianeptine free acid is a bit less orally bioavailable than Tianeptine sodium(CAS 30123-17-2), but would have the benefit of being absorbed more gradually - and thus would lead to a gentle rise in Tianeptine concentrations in the body, with sustained absorption for several hours - if consumed p.o. The free acid form is non hygroscopic and will not turn to goo if left exposed to the atmosphere.
Tianeptine free acid shares some properties with Tianeptine sulfate hemihydrate. Both are forms of Tianeptine that are non hygroscopic, much less soluble in water - and due to reduced solubility, appear to have sustained release characteristics.
Pharmacokinetic data is available for Tianeptine sodium(CAS 30123-17-2) salt, both in humans and in animal models. In contrast, pharmacokinetic data (absorption, distribution parameters, oral bioavailability, etc), do not appear to have been published, either for Tianeptine free acid or for Tianeptine sulfate. Overall oral bioavailability may vary between forms (factors such as particle size, polymorph, etc also play roles here). The molecular masses also vary for each of the forms.
2.There's limited published data on the stability of Tianeptine sodium(CAS 30123-17-2)
Based on the paper, Tianeptine sodium(CAS 30123-17-2) can be degraded by UV light:
"Photodecomposition of TIA - The stress testing revealed that TIA is more sensitive toward UV light than other environmental factors. Approximately 25% of the TIA content was lost after exposure of TIA powder to UV irradiation for 3h. The color of the powder TIA changed from white to brownish-yellow."
Tianeptine sodium(CAS 30123-17-2) is typically very hygroscopic - if left unsealed, it quickly absorbs moisture from the air, eventually forming a gel - which likely does not degrade the Tianeptine molecules per se, but makes weighing more or less useless and probably renders the Tianeptine more prone to rapid degradation.
As long as either Tianeptine sodium(CAS 30123-17-2) or Tianeptine free acid are kept sealed, cool, dry, and most importantly protected from sources of UV light, they will both be essentially stable over a 2-3 year timeframe.
Question2:
Answers:
1."I wanted to post.I've tried so many neuro drugs to help me for depression to basically just feel good about my life.I was able to order 80 grams of pure Tianeptine sodium(CAS 30123-17-2) from a chem company in China."
2."I want to add that the one thing that seemed to help at all with my depression was Tianeptine sodium(CAS 30123-17-2), but it gave me intolerable constipation both times."
3."Do you think that Tianeptine sodium(CAS 30123-17-2) is a necessary addition? It seems to me ...Something that would be able to turn down the volume to that structure, would be very effective for his kind of depression."
4."Hi I'm severly depressed and currently on Valdoxan, again. My doc first prescribed Valdoxan to fix my sleep routine and then suggested to continue with Tianeptine sodium(CAS 30123-17-2) to cure my depression."
5."But I wonder if it was spurred on by tianeptine, I ordered some Tianeptine sodium(CAS 30123-17-2) several months ago and started taking it and going to the gym and eating really healthy, I felt great.Then I ran out.
Question3:What's it like to take Tianeptine sulfate?
What's the difference between the Tianeptine sodium(CAS 30123-17-2) and Tianeptine sulfate? Is the sulfate less effective at boosting mood? I heard it's a bit more mellow then the sodium version. (I'm taking it for depression)
Answer:
Tianeptine Sulphate, also known as Tianeptine Hemisulfate Monohydrate, is a Tricyclic Anti-depressant (TCA) and as this might suggest, its predominant use is for the treatment of depression. With that said, Tianeptine is also used to treat anxiety disorders, asthma and even irritable bowel syndrome. The Science Behind it: This is a tricky question because Tianeptine sulphate is a relatively new compound that needs, and deserves, much more money invested in it for testing.What we do know is that Tianeptine Sulphate is closely related to Tianeptine sodium(CAS 30123-17-2), and acts in a very similar manner.  This is primarily due to the similarities in chemical structure, as can be seen in the diagram to the right.For those of you unfamiliar with Tianeptine sodium(CAS 30123-17-2), you may know it under the trade name ‘Coaxil’ across Europe and Asia or as ‘Stablon’ and ‘Tatinol’ across Latin America.  It is currently approved for medical use in 20 countries.